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Noteworthy, Plumel et al. [2] have recently highlighted the potential involvement of other non-energy based mechanisms through which reproductive costs may reduce life expectancy of females. This proposal is based on the finding that female mice with reduced litters (litter sizes decreased by 2 offspring 2 days after parturition) exhibit higher levels of liver regucalcin (a.k.a. senescence marker protein-30) than females with enlarged litters (litter sizes increased by 2 offspring 2 days after parturition) and control females with unmodified litter sizes. We should bear in mind that regucalcin is a calcium-binding protein, whose amino acid sequence appears to be highly conserved among vertebrates, that plays an important role in organism aging and survival. Actually, aging rats and senescence-accelerated mice display reduced levels of liver regucalcin, and knockout mice lacking this protein have shortened lifespans (for references, see Plumel et al. [2]). Although this mechanism is appealing, we should bear in mind that the liver samples used in the proteomic analysis performed by Plumel et al. [2] were taken from female mice culled just after their pups were weaned on day 21 after birth, time at which lactating dams are exposed to high energy demands (for review, see Speakman [1]). As no other proteomic determinations were performed at later ages, it is not possible from these data to ascertain whether changes in levels of liver regucalcin were either permanent or transitory.
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After passing through the door, the members of the order are the participants of the game in Splif for survival. Jesse becomes the only survivor and tries to use his sword, breaking the rules of the game. The rest of the team come alive, but go to the mines to extract quartz.
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180. If forms of property unknown in the past take on significant importance in the process of economic and social development, nonetheless, traditional forms of property must not be forgotten. Individual property is not the only legitimate form of ownership. The ancient form of community property also has a particular importance; though it can be found in economically advanced countries, it is particularly characteristic of the social structure of many indigenous peoples. This is a form of property that has such a profound impact on the economic, cultural and political life of those peoples that it constitutes a fundamental element of their survival and well-being. The defence and appreciation of community property must not exclude, however, an awareness of the fact that this type of property also is destined to evolve. If actions were taken only to preserve its present form, there would be the risk of tying it to the past and in this way compromising it[381].
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